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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of
《医学前沿(英文)》 doi: 10.1007/s11684-023-1010-1
关键词: exosomes induce activation impair function CD19 exosomal CD19 antigen
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 76-84 doi: 10.1007/s11684-015-0426-7
Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome (APS). However, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesis of thrombosis is not fully understood. In this report, we investigated the role of anti-β2GP I antibodies in complexes with β2GP I as mediators of platelet activation, which can serve as a potential source contributing to thrombosis. We examined the involvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2GP I complex. The interaction between the anti-β2GP I /β2GP I complex and platelets was examined using in vitro methods, in which the Fc portion of the antibody was immobilized using protein A coated onto a microtiter plate. Platelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression and thromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylation. Our results revealed that the anti-β2GP I /β2GP I complex was able to activate platelets, and this activation was inhibited by either the anti-GP I bα antibody or the apoER2' inhibitor. Results showed that the anti-β2GP I /β2GP I complex induced platelet activation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency in APS patients.
关键词: anti-β2GP I /β2GP I complex platelet GP I bα apoER2' thrombosis
Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via
Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu
《医学前沿(英文)》 2019年 第13卷 第6期 页码 680-689 doi: 10.1007/s11684-018-0673-5
关键词: anti-
Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 236-238 doi: 10.1007/s11684-017-0611-y
Recently, Ng . reported that the A:T>T:A substitutions, proposed to be a signature of aristolochic acid (AA) exposure, were detected in 76/98 (78%) of patients with hepatocellular carcinoma (HCC) from the Taiwan Province of China, and 47% to 1.7% of HCCs from the Chinese mainland and other countries harbored the nucleotide changes. However, other carcinogens, e.g., tobacco carcinogens 4-aminobiphenyl and 1,3-butadiene, air toxic vinyl chloride and its reactive metabolites chloroethylene oxide, melphalan and chlorambucil, also cause this signature in the genome. Since tobacco smoke is a worldwide public health threat and vinyl chloride distributes globally and is an air pollutant in Taiwan Province, the estimation of the patients’ exposure history is the key to determine the “culprit” of the A:T>T:A mutations. Apparently, without estimation of the patients’ exposure history, the conclusion of Ng is unpersuasive and misleading.
关键词: genomic signature carcinogen aristolochic acid tobacco smoke vinyl chloride hepatocellular carcinoma
Extracts from cotton over the whole growing season induce
Ming LANG, Rui YU, Yongqing MA, Wei ZHANG, Christopher S. P. McErlean
《农业科学与工程前沿(英文)》 2017年 第4卷 第2期 页码 228-236 doi: 10.15302/J-FASE-2017150
关键词: agricultural systems cotton crop ecology crop rotation systems weed management
Enhanced activation of peroxymonosulfate by CNT-TiO
Xuemin Hao, Guanlong Wang, Shuo Chen, Hongtao Yu, Xie Quan
《环境科学与工程前沿(英文)》 2019年 第13卷 第5期 doi: 10.1007/s11783-019-1161-0
关键词: Peroxymonosulfate activation Carbon nanotubes TiO2 Water treatment
外泌体CD44与整合素α6β4结合激活宿主细胞重塑肿瘤微环境促进胰腺癌恶性转移 Article
牟为, 许亚婕, 顾鹏飞, 王文斌, 李井泉, 葛阳, 王慧
《工程(英文)》 2021年 第7卷 第10期 页码 1415-1425 doi: 10.1016/j.eng.2020.08.013
绝大多数胰腺癌患者的死亡都是由于癌细胞迅速转移到肺、肝、脑等重要器官造成的。其中,胰腺癌肝转移是胰腺癌患者死亡率高的原因之一。来自胰腺癌细胞的外泌体通常富含跨膜蛋白,用于支持肿瘤微环境的重编程和远处转移性病变的进展。我们的研究发现,由外泌体传递的跨膜糖蛋白CD44通过重编程肿瘤微环境,参与了胰腺癌的转移过程。CD44与整合素α6β4相互作用形成复合物,激活细胞内骨架蛋白及其信号通路,进而调控Src和Ras信号级联反应,促进肿瘤细胞的运动。值得注意的是,我们还证明了CD44-α6β4复合物可以通过外泌体的旁分泌作用传递到靶区。肝细胞选择性摄取具有高表达CD44的肿瘤外泌体,并通过刺激细胞因子、促炎因子和生长因子产生转移前生态位,最终支持肿瘤转移。我们的研究结果表明,外泌体CD44有可能作为胰腺癌临床诊断和治疗的生物标志物。
《化学科学与工程前沿(英文)》 2023年 第17卷 第4期 页码 387-394 doi: 10.1007/s11705-022-2250-3
关键词: self-activation zinc organic salts abundant mesopores symmetric supercapacitor liquid electrolyte
《能源前沿(英文)》 2023年 第17卷 第4期 页码 545-554 doi: 10.1007/s11708-023-0867-7
《化学科学与工程前沿(英文)》 2022年 第16卷 第10期 页码 1485-1492 doi: 10.1007/s11705-022-2169-8
关键词: CH4 dissociation Ni–M C–H bond activation charge transfer
Optimal dynamic emergency reserve activation using spinning, hydro and demand-side reserves
S. Surender REDDY,P. R. BIJWE,A. R. ABHYANKAR
《能源前沿(英文)》 2016年 第10卷 第4期 页码 409-423 doi: 10.1007/s11708-016-0431-9
关键词: demand-side reserves dynamic reserve activation approach hydro power units post contingency sequential reserve activation approach spinning reserves
Application of liquid biopsy in precision medicine: opportunities and challenges
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 522-527 doi: 10.1007/s11684-017-0526-7
Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosis and treatment of individuals. Detecting circulating tumor cell (CTC) or circulating tumor DNA (ctDNA) in plasma or serum could serve as liquid biopsy, which would be useful for numerous diagnostic applications. Liquid biopsies can help clinicians screen and detect cancer early, stratify patients to the most suitable treatment and real-time monitoring of treatment response and resistance mechanisms in the tumor, evaluate the risk for metastatic relapse, and estimate prognosis. We summarized the advantages and disadvantages of tissue and liquid biopsies. We also further compared and analyzed the advantages and limitations of detecting CTCs, ctDNAs, and exosomes. Furthermore, we reviewed the literature related with the application of serum or plasma CTCs, ctDNAs, and exosomes for diagnosis and prognosis of cancer. We also analyzed their opportunities and challenges as future biomarkers. In the future, liquid biopsies could be used to guide cancer treatment. They could also provide the ideal scheme to personalize treatment in precision medicine.
关键词: liquid biopsy circulating tumor cells cell-free ctDNA exosomes precision medicine
Coronary leukocyte activation in relation to progression of coronary artery disease
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 85-90 doi: 10.1007/s11684-016-0435-1
Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.
关键词: coronary artery disease inflammation integrin myeloperoxidase leukocyte activation
NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway
《医学前沿(英文)》 2023年 第17卷 第2期 页码 263-274 doi: 10.1007/s11684-022-0935-0
关键词: melanoma neuropilin and tolloid-like 2 Ca2+/CaMKII signaling pathway
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1706-0
● A CNT filter enabled effective KMnO4 activation via facilitated electron transfer.
关键词: KMnO4 Carbon nanotubes Non-radical pathway Electron transfer Water treatment
标题 作者 时间 类型 操作
Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of
期刊论文
Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two
null
期刊论文
Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via
Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu
期刊论文
Extracts from cotton over the whole growing season induce
Ming LANG, Rui YU, Yongqing MA, Wei ZHANG, Christopher S. P. McErlean
期刊论文
Enhanced activation of peroxymonosulfate by CNT-TiO
Xuemin Hao, Guanlong Wang, Shuo Chen, Hongtao Yu, Xie Quan
期刊论文
Hierarchical porous carbon derived from one-step self-activation of zinc gluconate for symmetric supercapacitors
期刊论文
Enhanced performance of oxygen vacancies on CO adsorption and activation over different phases of ZrO
期刊论文
A density functional theory study of methane activation on MgO supported NiM cluster: role of M on C–Hactivation
期刊论文
Optimal dynamic emergency reserve activation using spinning, hydro and demand-side reserves
S. Surender REDDY,P. R. BIJWE,A. R. ABHYANKAR
期刊论文